The history of interactions between Muslims and the other cultures of the world is one of painful conflicts. In some cases, these conflicts have been based on accurate mutual perceptions: when Islam looks at other world cultures and accuses them of lowering their moral standards, Islam is correct. When Islam has made the assessment that the Judeo-Christian religious tradition is incompatible with the core teachings of Islam, because Islam rejects the concept of a God who loves and forgives unconditionally, Islam is correct in that assessment.
Sometimes conflicts are based on actual disagreements, such as the two listed above. Muslims are correct that other world cultures have lowered their moral standards: when one considers alcohol abuse, other forms of drug abuse, tobacco use, premarital sex, and other forms of inappropriate sexual activity, it is clear that there is a moral gap between Islam and the rest of the world. Muslims are correct when they judge that other religions are incompatible with their own: the Judeo-Christian tradition teaches that humans cannot merit or earn God's favor or forgiveness, but rather that He gives it freely and unconditional to those who do not deserve it; a Muslim cannot accept that view of God.
But sometimes conflicts are based, not on real differences, but on perceived differences. Mis-perceptions can create the impression of disagreements, even when there are none. Four examples: Muslims sometimes perceive Christians as polytheists, because of the concept of the Trinity; but in fact, Christians are as monotheistic as Muslims, and core of the concept of the Trinity is monotheistic. Muslims sometimes perceive that there cannot be a father-son relationship between God the Father and God the Son; yet in the Qur'an and other Muslim writings, paternal and filial language is used to describe Allah's spiritual fatherhood. Muslims sometimes perceive the execution of Jesus as unbelievable; but the historical record of Roman rule in the province of Judea makes such an execution entirely in keeping with the rule of Roman governor like Pilate. Muslims sometimes perceive the written records of non-Islamic cultures as unreliable; but the historical records of the ancient world are verifiable and have shown themselves to be at least as accurate as Islamic histories.
There are enough real differences between Islam and the rest of the world to create problems; the situation is complicated by fictional differences as well.